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Actividad antibacteriana, antifúngica y otras aplicaciones de dendrímeros con núcleos del tipo calixareno y/o resorcinareno: Revisión del estado del arte

dc.contributor.advisorEstupiñan Torres, Sandra Mónica
dc.contributor.advisorRivera Monroy, Zuly Jenny
dc.contributor.advisorPineda Castañeda, Héctor Manuel
dc.contributor.authorHernandez Pardo, Andrea Carolina
dc.date.accessioned2022-06-14T19:14:15Z
dc.date.available2022-06-14T19:14:15Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.universidadmayor.edu.co/handle/unicolmayor/5603
dc.description.abstractLa resistencia antimicrobiana (RAM) es una de las diez amenazas principales a la salud pública reportadas por la Organización Mundial de la Salud (OMS)1 . Una de las principales causas del creciente problema de la RAM, es la falta de nuevas terapias y/o agentes; en consecuencia, muchas enfermedades infecciosas podrían volverse incontrolables2 . La creciente aparición de microorganismos multidrogorresistentes (MDR), viene ligada a una inapropiada administración y uso excesivo de antimicrobianos en humanos y animales generando un aumento considerable de la resistencia a los tratamientos convencionales3,4 . Dado el crecimiento acelerado y la expansión global de la RAM se ha impulsado la necesidad de descubrir nuevos agentes antimicrobianos que logren mitigar esta problemática. Los dendrímeros con actividad antimicrobiana son una alternativa de tratamiento, estas macromoléculas con estructura simétrica bien definida y arquitectura tridimensional han demostrado ser buenos agentes antimicrobianos y antibiofilm. Estos polímeros cuentan con una estructura tridimensional bien definida y altamente ramificada, la cual puede ser prediseñada y modificada en la síntesis para obtener moléculas con características físicas y químicas específicas7 La mayoría de los derivados incluidos en esta monografía muestran una buena actividad antimicrobiana frente a bacterias y hongos, teniendo en cuenta diferentes caracteristicas, como el tipo de bacteria, hongo o aislado, la clase de sustituyente y la distribución espacial de las moléculas. Considerando que aun quedan muchos retos en esta línea de investigación.spa
dc.description.tableofcontentsResumen 8 1. Introducción 9 2. Antecedentes 14 3. Marco teórico 17 3.1. Dendrímeros basados en compuestos de tipo calix[n]areno y calix[n]resorcinareno 17 3.2. Relación estructura actividad de dendrímeros derivados de calix[n]arenos y calix[n]resorcinarenos 22 4. Diseño Metodológico 25 4.1. Tipo de investigación 25 4.2. Universo, población y Muestra 25 4.2.1. Universo 25 4.2.2. Población 25 4.2.3. Muestra 25 5. Metodología 25 5.1. Revisión bibliográfica 25 6. Resultados y discusión 26 6.1. Revisión bibliográfica 26 6.2. Actividad antimicrobiana 27 6.2.1. Actividad antibacteriana 27 6.2.2. Actividad antifúngica 47 6.2.3. Otras aplicaciones 54 6.2.3.1. Actividad antiviral 54 6.2.3.2. Actividad antiparasitaria 58 6.2.3.3. Actividad anticancerígena 60 7 7. Conclusiones 70 Referencias Bibliográficas 71 Anexos 79 Anexo 1. Actividad de dendrímeros en células plantónicas. 79 Anexo 2. Actividad de dendrímeros sobre biofilm 92 Anexo 3. Actividad de dendrímeros virus y parásitos 95 Anexo 4. Actividad anticancerígena de los dendrímeros 97spa
dc.format.extent109p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2021eng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleActividad antibacteriana, antifúngica y otras aplicaciones de dendrímeros con núcleos del tipo calixareno y/o resorcinareno: Revisión del estado del artespa
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá DCspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembResorcinareno
dc.subject.lembRAM
dc.subject.lembCitotoxicidad
dc.subject.proposalDendrímerospa
dc.subject.proposalCalixarenospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.rights.coarhttp://purl.org/coar/access_right/c_14cbspa


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